Pyspade

1. Fix bug in DEobs and DErand
2. Fix bug in process

1. Add self-defined background cells in fc.
2. Speed up global function.
3. Fix bug in the local function.
4. Improve performance of large datasets in DEobs and DErand.

1. Fix bug in the Manhattan function

1. Fix bugs in the Manhattan function
2. Fix bugs in the local function

1. Check fc query gene list first to avoid inconsistent gene
2. Add chrY genes in the annotation file
3. Model the background distribution as gamma distribution
4. Add up-regulation results of local function
5. Add manhattan function to generate Manhattan plots automatically
6. Add the self-defined background cells in the DEobs

1. Implement empirical p-value in local and global function
2. Add no CellPlex option in process function
3. Change fc output format
[pySpade-0.0.4.tar.gz](https://github.com/Hon-lab/pySpade/files/13789907/pySpade-0.0.4.tar.gz)