This is the first release of *sbmodelr*, version 1.0
Build-295
The COPASI team announces the immediate availability of the stable release COPASI 4.44 (Build 295).
A new release of COPASI has been made available. Please visit our [free download](https://copasi.org//Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](https://copasi.org//Download/License/), which is an [OSI](https://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Bug Fixes
* Command Line (CopasiSE)
* No files are created or modified when the option --validate is given.
* Simulation Engine
* Time Course Task: The methods RADAU5 not correctly supports the option Suppress Output Before ...
* Time Course Task: The hybrid methods Hybrid LSODA & Hybrid Runge-Kutta now supports automatic step size correctly.
* Optimization and Parameter Estimation Tasks: The method Praxis now correctly terminates if the if solution is within the tolerance.
* Parameter Estimation Task: The Method Evolution Strategy (SRES) checks not the functional constraints like other methods.
* Metabolic Control Analysis and Linear Noise Approximation Tasks: The result now contains the Steady-State result.
More information can be found in the
[changelog](https://copasi.org//Support/Change_History/COPASI_4_44_Build_295/).
Build-288
The COPASI team announces the immediate availability of the stable release COPASI 4.43 (Build 288).
A new release of COPASI has been made available. Please visit our [free download](https://copasi.org//Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](https://copasi.org//Download/License/), which is an [OSI](https://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Standards
* SBML: Added support of SBML Level 3 Version 2
Bug Fixes
* Graphical User Interface (CopasiUI)
* Event Overview: The assignments associated with an event are no properly displayed.
* Optimization: Changing of the subtask is now preserved without running the optimization task.
* Task and subtask names are now consistently handled in sensitivities, optimization, and scan.
* Scan Task: Improved handling of output from subtask by allowing finer control over when output is captured.
* Simulation Engine
* Fix calculations involving constant rates which were in certain situations (e.g. event assignments) not correctly updated.
* Language Bindings
* In the case that multiple data models with the same name where loaded simultaneously, renaming an object in one data model does not longer effect references the other models.
* Setting CCopasiParameter values directly will now result in a call to the parent group to assure proper synchronization of related parameters.
More information can be found in the
[changelog](https://copasi.org//Support/Change_History/COPASI_4_43_Build_288/).
Build-284
The COPASI team announces the immediate availability of the stable release COPASI 4.42 (Build 284).
A new release of COPASI has been made available. Please visit our [free download](https://copasi.org//Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](https://copasi.org//Download/License/), which is an [OSI](https://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Simulation Engine
* Scan task: implemented support iterating through parameter sets.
* Optimization & Parameter Estimation: It is now possible to run current solution statistics before adding any optimization parameters.
Bug Fixes
* Graphical User Interface (CopasiUI)
* Fixed issue were results of tasks were not properly displayed after the first run of the task.
* Fixed scan task to correctly show parameter estimation results.
More information can be found in the
[changelog](https://copasi.org//Support/Change_History/COPASI_4_42_Build_284/).
Build-283
The COPASI team announces the immediate availability of the stable release COPASI 4.41 (Build 283).
A new release of COPASI has been made available. Please visit our [free download](https://copasi.org//Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](https://copasi.org//Download/License/), which is an [OSI](https://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: November 21, 2023
New Features
* Simulation Engine
* Species particle numbers are no supported as event targets.
* Optimization & Parameter Estimation: It is now possible to run current solution statistics before adding any optimization parameters.
Bug Fixes
* Graphical User Interface (CopasiUI)
* Reduced COPASI's start up time.
* Fixed display of message boxes under Qt 6.5.
* Improved functionality and stability of the plotting engines QWT & QCustomPlot
* The output assistant suppresses now any check boxes which are not applicable to the current task.
* Improved display of SBML imported units.
* Fixed rare crash occurring when lading a new file while displaying a global quantity.
* Simulation Engine
* Utilize balanced Abstract Syntax Tree to avoid stack overflows.
* Fixed loading of COPASI files containing parameter estimation created with COPASI 4.0 (Build 18).
* The COPASI Version is now correctly displayed in reports.
* Fixed an error message for trajectory method RK45 which was referring to LSODA.
* Standards
* SBML Import: Corrected function parameter classification which effected the UI parameter overview.
* SBML Import: Avoid redundant division by log(10) when importing logarithm with base 10.
* SBML Import (layout): Allow import of empty curves.
* SED-ML Import: Improved import of SED-ML files with multiple task lists, falling back to SBML when all fail.
* SED-ML Import: Create a warning message when referenced the SBML model is remote resource (unsupported).
* API & Language Bindings
* Added utility function CFunctionDB::purgeUnusedUserDefinedFunctions().
* Added editing of constraints in optimization and parameter estimation tasks.
More information can be found in the
[changelog](https://copasi.org//Support/Change_History/COPASI_4_41_Build_283/).
Build-278
The COPASI team announces the immediate availability of the stable release COPASI 4.40 (Build 278).
A new release of COPASI has been made available. Please visit our [free download](https://copasi.org//Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](https://copasi.org//Download/License/), which is an [OSI](https://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: May 31, 2023
New Features
* The is a bug fix release and does not include new features
Bug Fixes
* Graphical User Interface (CopasiUI)
* Fixed issue where loading a parameter estimation protocol in which the values had been sorted externally lead to incorrect parameter mapping.
* Show both modification and creation time entities in local time.
* Fixed plot for parameter estimation results for steady state experiments to properly map the independent data.
* The parameter estimation result now includes a counter for failed constraints.
* Fixed crash when deleting all global quantities.
* Simulation Engine
* Fixed temporary directory for export of Combine and Shiny archives to address security restrictions on MacOS X.
* Stochastic simulation methods now correctly report whether they support events and thus whether they can be used for the simulation of model with events.
* Standards
* SBML import: Fixed issue where it was not possible to change the delay of an imported event.
* SBML import: Fixed crash caused by particular unit definitions during importing.
* SBML import: Fixed import of reaction kinetics which occasionally lost the parameter mapping.
* SBML import: Handle references to missing modifier species in reactions gracefully.
* SBML export: Reduced warnings about Model History not being exported to only check the model itself and not all model components.
More information can be found in the
[changelog](https://copasi.org//Support/Change_History/COPASI_4_40_Build_278/).
Build-272
The COPASI team announces the immediate availability of the stable release COPASI 4.38 (Build 272).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: January 31, 2023
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_39_Build_272/).
Build-268
The COPASI team announces the immediate availability of the stable release COPASI 4.38 (Build 268).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: November 30, 2022
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_38_Build_268/).
Build-264
The COPASI team announces the immediate availability of the stable release COPASI 4.37 (Build 264).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: October 5, 2022
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_37_Build_264/).
Build-260
The COPASI team announces the immediate availability of the stable release COPASI 4.36 (Build 260).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: May 16, 2022
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_36_Build_260/).
Build-258
The COPASI team announces the immediate availability of the stable release COPASI 4.35 (Build 258).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: March 15, 2022
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_35_Build_258/).
Build-251
The COPASI team announces the immediate availability of the stable release COPASI 4.34 (Build 251).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: August 12, 2021
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_34_Build_251/).
Build-246
The COPASI team announces the immediate availability of the stable release COPASI 4.33 (Build 246).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Bug Fixes
* Simulation Engine
* Fixed problem for models with species of type ODE, for which no simulation or analysis was possible.
Release Date: June 17, 2021
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_33_Build_246/).
Build-245
The COPASI team announces the immediate availability of the stable release COPASI 4.32 (Build 245).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Installation
* The Linux installation support parallel installation of COPASI versions.associations.
* Language Bindings
* Exposed SED-ML exporter.
Release Date: June 16, 2021
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_32_Build_245/).
Build-243
The COPASI team announces the immediate availability of the stable release COPASI 4.31 (Build 243).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Installation
* The Linux installation has been changed to a self extracting interactive archive which also creates a desktop file and registers file and URL associations.
* Language Bindings
* Exposed the MIRIAM annotation in the language bindings.
Release Date: May 10, 2021
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_31_Build_243/).
Build-240
The COPASI team announces the immediate availability of the stable release COPASI 4.30 (Build 240).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Graphical User Interface (CopasiUI)
* Added intensive reaction flux to the steady-state results relevant for small compartments.
* Simulation Engine
* Added Just In Time compilation of all user defined mathematical expression to assembler code significantly improving COPASI's [performance](http://copasi.org/News/2021/02/24/COPASI/).
* Language Bindings
* It is now possible to capture data generated from tasks directly without using a temporary file.
Release Date: February 24, 2021
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_30_Build_240/).
Build-228
The COPASI team announces the immediate availability of the stable release COPASI 4.29 (Build 228).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Graphical User Interface (CopasiUI)
* Time course fluxes are now shown in the layout when playing back a time course.
* The number of reactions a species is involved in is now shown in the species table.
Release Date: August 11, 2020
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_29_Build_228/).
Build-226
The COPASI team announces the immediate availability of the stable release COPASI 4.28 (Build 226).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Graphical User Interface (CopasiUI)
* Performance improvements while switching to tables of species and reactions or the parameter overview
for large models through deferred loading.
* Added line numbers to table of items in the report definition widget.
* It is now possible to add/merge SBML models to the currently loaded model.
* It is no possible to change the order of plot items and thus controlling the order in the legend.
* Simulation Engine
* Added additional convergence criterion to the steady state calculation. The user can chose between
distance, rate, or both (default).
* Added advanced parameter to the Levenberg Marquardt method adjusting the step increase/decrease strategy.
* Language Bindings
* The model analyzing tool is now available.
Release Date: June 12, 2020
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_28_Build_226/).
Build-217
The COPASI team announces the immediate availability of the stable release COPASI 4.27 (Build 217).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This release has several new features:
* Graphical User Interface (CopasiUI)
* Fixed missing application icon on Mac OS X.
* In rare occasions it was possible that the COPASI file was corrupted when simultaneously checking for new updates and saving a file.
* Simulation Engine
* Fixed a problem where COPASI incorrectly reported a steady-state due to a singular Jacobian.
* Fixed a problem where a scan task caused an exception due to incomplete specification.
Release Date: September 14, 2019
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_27_Build_217/).
Build-213
The COPASI team announces the immediate availability of the stable release COPASI 4.26 (Build 213).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This release has several new features:
* Graphical User Interface (CopasiUI)
* Added feature to open files directly from a web page which use the link format: 'copasi://'.
* It is to possible to specify a user selected list of time point for output in the trajectory tasks.
* It is now possible to enable automated checks for updates of COPASI as you are used to in many other applications.
* We added a tool to remove SBML Ids from the COPASI file which are used to facilitate referencing the original SBML Id on export. When an object was renamed the original SBML Id is preserved which is desired in most cases. However there are circumstances where this behavior is not desired. Removing the SBML Ids leads to newly created Id based on the names in COPASI.
* A COPASI file downloaded using the 'Open URL' method has the targets of reports removed so that a malicious user cannot automatically create harmful content.
* Command-line (CopasiSE)
* Added option to export ant import different parameterizations of the model through simple ini file.
Release Date: July 31, 2019
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_26_Build_213/).
Build-207
The COPASI team announces the immediate availability of the stable release COPASI 4.25 (Build 207).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This release has several new features:
* Graphical User Interface (CopasiUI)
* Added capability to load and save model parameter sets from files.
* Moiety results are now displayed according to the framework, i.e. in amount units or particle numbers.
* Added default report moiety task
* Advanced rarely used method parameters are no hidden if they are at default setting. The user can change this behavior through the preference dialog.
* Combine archive are can now be opened via drag and drop like all other supported formats.
* Added additional plot type supporting banded graphs.
* Added the capability to open files directly from an URL under the file menu.
* Added Lyapunov exponents to the selectable result in the object selection widget.
* Command-line (CopasiSE)
* Added option to convert the model reactions to irreversible
* Added option to specify the task to be executed
* Added option to override the report file name to be used.
* Language Bindings
* The sed-ml and combine archive functionalities are now exposed in the language bindings.
Release Date: March 15, 2019
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_25_Build_207/).
Build-197
The COPASI team announces the immediate availability of the stable release COPASI 4.24 (Build 197).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This is mainly a bug fix release with some GUI improvements:
* Graphical User Interface
* Implemented a new 3d bar graph view of matrixes allowing for better selection of interesting values. The new view also avoids OpenGL issues due to incomplete graphic card support of the OS.
* Improved issue display in the object browser which did not recognize missing expressions for entities of type ODE and occasionally marked missing initial expressions when not required.
* Improved display of advanced method parameters. If advanced parameter usage is indicated in the preferences they will be shown last. If it is not selected non advanced parameters which are not at their value will be shown to inform the user.
* SBML
* Models which explicitely reference Avogadro's number can now be exported to SBML.
Release Date: July 30, 2018
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_24_Build_197/).
Build-184
The COPASI team announces the immediate availability of the stable release COPASI 4.23 (Build 184).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the
[Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This release includes many new features:
New Features
* Graphical User Interface
* Model Merging: COPASI allows to add a second model and to merge its content with the existing one.
* Compartment dimensionality may now be specified as: volume, area, length, or dimensionless.
* Problems (Errors, Warnings) of the model are no marked in the object browser at the problematic entity.
* Enhanced Unit Support for kinetic parameters.
* Import and export of Combine Archive is now supported.
* The full and reduced Jacobian of the current model state are now shown under Model/Mathematical/Matrices.
* Enable copying table and annotated matrix items to the clipboard.
* A warning is now raised when loading an invalid model (i.e: one that does not compile) and the problematic
entity is marked in the browser pane.
* Added ability to add COPASI version, current date/time, first name, last name, email and organization as
well as line breaks to a reports.
* Allow for the selection of matrices in Object Browser expert mode.
* Plots can be associated with tasks similar to the existing report association
* The direct dependencies, i.e, the objects which are directly effected by changes or removal of an
entity are now displayed on all modeling entities.
* Simulation Engine
* COPASI supports Stochastic Differential Equations (SDEs). It is possible to add noise to reactions and
entities (compartments, species, and global quantities) determined by ODEs.
Release Date: April 18, 2018
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_23_Build_184/).
Build-170
The COPASI team announces the immediate availability of the stable release COPASI 4.22 (Build 170).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the
[Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. The main improvement in this release is the significantly increased performance.
Release Date: November 10, 2017
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_22_Build_170/).
Build-166
The COPASI team announces the immediate availability of the stable release COPASI 4.21 (Build 166).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the
[Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. The main improvement in this release is the significantly increased performance.
Release Date: October 09, 2017
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_21_Build_166/).
Build-158
The COPASI team announces the immediate availability of the stable release COPASI 4.20 (Build 158).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This is mainly a bug fix release and with the following new features:
* Graphical User Interface (CopasiUI)
* It is now possible to export the rendered mathematical expressions to a PDF document.
* The application window remembers the size of the window and the with of the left browser pane to avoid frequent adjustment by the user.
* Plots can now be activated and deactivated in the plot itself.
* When an experimental data file is not found at the expected location COPASI allows now specify a new location by opening a file open dialog.
* Simulation Engine
* The Avogadro symbol can now be used in user defined functions.
Release Date: July 31, 2017
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_20_Build_158/).
Build-140
The COPASI team announces the immediate availability of the stable release COPASI 4.19 (Build 140).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This is a bug fix release which fixes an access violation crash.
Release Date: January 12, 2017
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_19_Build_140/).
Build-136
The COPASI team announces the immediate availability of the stable release COPASI 4.18 (Build 136).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This is a bug fix release which fixes an access violation crash.
Release Date: November 28, 2016
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_18_Build_136/).
Build-135
The COPASI team announces the immediate availability of the stable
release COPASI 4.17 (Build 135).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: November 21, 2016
New Features since COPASI 4.16 (Build 104)
- Graphical User Interface (CopasiUI)
- Support for user defined units.
- Extended unit selection options for time, volume and quantity of the model. These extended options include user defined units.
- Unit support for Global Quantities.
- Undo and redo support for all model changes.
- Improved user interface to method parameters.
- Selection of matrix and vector elements by name in addition to the index for plots, reports, and in mathematical expressions.
- Support for contour plots.
- Sorting off all analysis result tables is now enabled where appropriate.
- The MCA results contain now information whether the summation theorems are violated or not allowing the user to easily evaluate the numerical accuracy of the result.
- It is now possible to the select the units of the rate low for a reaction as either amount per time or concentration per time. If concentration per time is selected and the reaction participates in multiple compartments the scaling compartment can be selected.
- Simulation Engine
- Added support for arbitrary events to the Stochastic Direct Method.
- New hybrid simulation algorithm: (Hybrid RK-45) which supports arbitrary discrete events and user defined ODEs. Additionally, the user can specify which reaction are treated continuously and which are treated discretely. This algorithm passes the SBML semantic test suite and stochastic suite.
- It is now possible to report or plot only the internal steps taken by the integration algorithm in the trajectory task.
- SBML
- Full support for SBML Level 3.1 event semantics
- Import and export of unit definitions.
- SBOTerms are no imported and displayed as part of the MIRIAM annotation. On export a the first SBOTerm of the MIRIAM annotation is used if the SBML entity does not have the SBOTerm set.
A list of resolved issues can be found in the
[changelog]({{ site.baseurl }}/Support/Change_History/COPASI_4_17_Build_135/).
Build-104
New Features since COPASI 4.15 (Build 95)
- Graphical User Interface (CopasiUI)
- The copy to next feature in the Experimental data description
dialog is now able to handle the situation were the target
experiment has less columns than the copied one.
- Simulation Engine
- The Gamma distribution and the Poisson distribution are now
accessible in mathematical expressions and exported to SBML.
- SBML
- COPASI now exports the SBML L1V1 legacy format.
A list of resolved issues can be found in the
[changelog](http://copasi.org/Support/Change_History/COPASI_4_16_Build_104/).
Build-95
Build-295
The COPASI team announces the immediate availability of the stable release COPASI 4.44 (Build 295).
A new release of COPASI has been made available. Please visit our [free download](https://copasi.org//Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](https://copasi.org//Download/License/), which is an [OSI](https://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Bug Fixes
* Command Line (CopasiSE)
* No files are created or modified when the option --validate is given.
* Simulation Engine
* Time Course Task: The methods RADAU5 not correctly supports the option Suppress Output Before ...
* Time Course Task: The hybrid methods Hybrid LSODA & Hybrid Runge-Kutta now supports automatic step size correctly.
* Optimization and Parameter Estimation Tasks: The method Praxis now correctly terminates if the if solution is within the tolerance.
* Parameter Estimation Task: The Method Evolution Strategy (SRES) checks not the functional constraints like other methods.
* Metabolic Control Analysis and Linear Noise Approximation Tasks: The result now contains the Steady-State result.
More information can be found in the
[changelog](https://copasi.org//Support/Change_History/COPASI_4_44_Build_295/).
Build-288
The COPASI team announces the immediate availability of the stable release COPASI 4.43 (Build 288).
A new release of COPASI has been made available. Please visit our [free download](https://copasi.org//Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](https://copasi.org//Download/License/), which is an [OSI](https://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Standards
* SBML: Added support of SBML Level 3 Version 2
Bug Fixes
* Graphical User Interface (CopasiUI)
* Event Overview: The assignments associated with an event are no properly displayed.
* Optimization: Changing of the subtask is now preserved without running the optimization task.
* Task and subtask names are now consistently handled in sensitivities, optimization, and scan.
* Scan Task: Improved handling of output from subtask by allowing finer control over when output is captured.
* Simulation Engine
* Fix calculations involving constant rates which were in certain situations (e.g. event assignments) not correctly updated.
* Language Bindings
* In the case that multiple data models with the same name where loaded simultaneously, renaming an object in one data model does not longer effect references the other models.
* Setting CCopasiParameter values directly will now result in a call to the parent group to assure proper synchronization of related parameters.
More information can be found in the
[changelog](https://copasi.org//Support/Change_History/COPASI_4_43_Build_288/).
Build-284
The COPASI team announces the immediate availability of the stable release COPASI 4.42 (Build 284).
A new release of COPASI has been made available. Please visit our [free download](https://copasi.org//Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](https://copasi.org//Download/License/), which is an [OSI](https://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Simulation Engine
* Scan task: implemented support iterating through parameter sets.
* Optimization & Parameter Estimation: It is now possible to run current solution statistics before adding any optimization parameters.
Bug Fixes
* Graphical User Interface (CopasiUI)
* Fixed issue were results of tasks were not properly displayed after the first run of the task.
* Fixed scan task to correctly show parameter estimation results.
More information can be found in the
[changelog](https://copasi.org//Support/Change_History/COPASI_4_42_Build_284/).
Build-283
The COPASI team announces the immediate availability of the stable release COPASI 4.41 (Build 283).
A new release of COPASI has been made available. Please visit our [free download](https://copasi.org//Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](https://copasi.org//Download/License/), which is an [OSI](https://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: November 21, 2023
New Features
* Simulation Engine
* Species particle numbers are no supported as event targets.
* Optimization & Parameter Estimation: It is now possible to run current solution statistics before adding any optimization parameters.
Bug Fixes
* Graphical User Interface (CopasiUI)
* Reduced COPASI's start up time.
* Fixed display of message boxes under Qt 6.5.
* Improved functionality and stability of the plotting engines QWT & QCustomPlot
* The output assistant suppresses now any check boxes which are not applicable to the current task.
* Improved display of SBML imported units.
* Fixed rare crash occurring when lading a new file while displaying a global quantity.
* Simulation Engine
* Utilize balanced Abstract Syntax Tree to avoid stack overflows.
* Fixed loading of COPASI files containing parameter estimation created with COPASI 4.0 (Build 18).
* The COPASI Version is now correctly displayed in reports.
* Fixed an error message for trajectory method RK45 which was referring to LSODA.
* Standards
* SBML Import: Corrected function parameter classification which effected the UI parameter overview.
* SBML Import: Avoid redundant division by log(10) when importing logarithm with base 10.
* SBML Import (layout): Allow import of empty curves.
* SED-ML Import: Improved import of SED-ML files with multiple task lists, falling back to SBML when all fail.
* SED-ML Import: Create a warning message when referenced the SBML model is remote resource (unsupported).
* API & Language Bindings
* Added utility function CFunctionDB::purgeUnusedUserDefinedFunctions().
* Added editing of constraints in optimization and parameter estimation tasks.
More information can be found in the
[changelog](https://copasi.org//Support/Change_History/COPASI_4_41_Build_283/).
Build-278
The COPASI team announces the immediate availability of the stable release COPASI 4.40 (Build 278).
A new release of COPASI has been made available. Please visit our [free download](https://copasi.org//Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](https://copasi.org//Download/License/), which is an [OSI](https://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: May 31, 2023
New Features
* The is a bug fix release and does not include new features
Bug Fixes
* Graphical User Interface (CopasiUI)
* Fixed issue where loading a parameter estimation protocol in which the values had been sorted externally lead to incorrect parameter mapping.
* Show both modification and creation time entities in local time.
* Fixed plot for parameter estimation results for steady state experiments to properly map the independent data.
* The parameter estimation result now includes a counter for failed constraints.
* Fixed crash when deleting all global quantities.
* Simulation Engine
* Fixed temporary directory for export of Combine and Shiny archives to address security restrictions on MacOS X.
* Stochastic simulation methods now correctly report whether they support events and thus whether they can be used for the simulation of model with events.
* Standards
* SBML import: Fixed issue where it was not possible to change the delay of an imported event.
* SBML import: Fixed crash caused by particular unit definitions during importing.
* SBML import: Fixed import of reaction kinetics which occasionally lost the parameter mapping.
* SBML import: Handle references to missing modifier species in reactions gracefully.
* SBML export: Reduced warnings about Model History not being exported to only check the model itself and not all model components.
More information can be found in the
[changelog](https://copasi.org//Support/Change_History/COPASI_4_40_Build_278/).
Build-272
The COPASI team announces the immediate availability of the stable release COPASI 4.38 (Build 272).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: January 31, 2023
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_39_Build_272/).
Build-268
The COPASI team announces the immediate availability of the stable release COPASI 4.38 (Build 268).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: November 30, 2022
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_38_Build_268/).
Build-264
The COPASI team announces the immediate availability of the stable release COPASI 4.37 (Build 264).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: October 5, 2022
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_37_Build_264/).
Build-260
The COPASI team announces the immediate availability of the stable release COPASI 4.36 (Build 260).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: May 16, 2022
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_36_Build_260/).
Build-258
The COPASI team announces the immediate availability of the stable release COPASI 4.35 (Build 258).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: March 15, 2022
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_35_Build_258/).
Build-251
The COPASI team announces the immediate availability of the stable release COPASI 4.34 (Build 251).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: August 12, 2021
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_34_Build_251/).
Build-246
The COPASI team announces the immediate availability of the stable release COPASI 4.33 (Build 246).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Bug Fixes
* Simulation Engine
* Fixed problem for models with species of type ODE, for which no simulation or analysis was possible.
Release Date: June 17, 2021
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_33_Build_246/).
Build-245
The COPASI team announces the immediate availability of the stable release COPASI 4.32 (Build 245).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Installation
* The Linux installation support parallel installation of COPASI versions.associations.
* Language Bindings
* Exposed SED-ML exporter.
Release Date: June 16, 2021
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_32_Build_245/).
Build-243
The COPASI team announces the immediate availability of the stable release COPASI 4.31 (Build 243).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Installation
* The Linux installation has been changed to a self extracting interactive archive which also creates a desktop file and registers file and URL associations.
* Language Bindings
* Exposed the MIRIAM annotation in the language bindings.
Release Date: May 10, 2021
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_31_Build_243/).
Build-240
The COPASI team announces the immediate availability of the stable release COPASI 4.30 (Build 240).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Graphical User Interface (CopasiUI)
* Added intensive reaction flux to the steady-state results relevant for small compartments.
* Simulation Engine
* Added Just In Time compilation of all user defined mathematical expression to assembler code significantly improving COPASI's [performance](http://copasi.org/News/2021/02/24/COPASI/).
* Language Bindings
* It is now possible to capture data generated from tasks directly without using a temporary file.
Release Date: February 24, 2021
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_30_Build_240/).
Build-228
The COPASI team announces the immediate availability of the stable release COPASI 4.29 (Build 228).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Graphical User Interface (CopasiUI)
* Time course fluxes are now shown in the layout when playing back a time course.
* The number of reactions a species is involved in is now shown in the species table.
Release Date: August 11, 2020
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_29_Build_228/).
Build-226
The COPASI team announces the immediate availability of the stable release COPASI 4.28 (Build 226).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
New Features
* Graphical User Interface (CopasiUI)
* Performance improvements while switching to tables of species and reactions or the parameter overview
for large models through deferred loading.
* Added line numbers to table of items in the report definition widget.
* It is now possible to add/merge SBML models to the currently loaded model.
* It is no possible to change the order of plot items and thus controlling the order in the legend.
* Simulation Engine
* Added additional convergence criterion to the steady state calculation. The user can chose between
distance, rate, or both (default).
* Added advanced parameter to the Levenberg Marquardt method adjusting the step increase/decrease strategy.
* Language Bindings
* The model analyzing tool is now available.
Release Date: June 12, 2020
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_28_Build_226/).
Build-217
The COPASI team announces the immediate availability of the stable release COPASI 4.27 (Build 217).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This release has several new features:
* Graphical User Interface (CopasiUI)
* Fixed missing application icon on Mac OS X.
* In rare occasions it was possible that the COPASI file was corrupted when simultaneously checking for new updates and saving a file.
* Simulation Engine
* Fixed a problem where COPASI incorrectly reported a steady-state due to a singular Jacobian.
* Fixed a problem where a scan task caused an exception due to incomplete specification.
Release Date: September 14, 2019
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_27_Build_217/).
Build-213
The COPASI team announces the immediate availability of the stable release COPASI 4.26 (Build 213).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This release has several new features:
* Graphical User Interface (CopasiUI)
* Added feature to open files directly from a web page which use the link format: 'copasi://'.
* It is to possible to specify a user selected list of time point for output in the trajectory tasks.
* It is now possible to enable automated checks for updates of COPASI as you are used to in many other applications.
* We added a tool to remove SBML Ids from the COPASI file which are used to facilitate referencing the original SBML Id on export. When an object was renamed the original SBML Id is preserved which is desired in most cases. However there are circumstances where this behavior is not desired. Removing the SBML Ids leads to newly created Id based on the names in COPASI.
* A COPASI file downloaded using the 'Open URL' method has the targets of reports removed so that a malicious user cannot automatically create harmful content.
* Command-line (CopasiSE)
* Added option to export ant import different parameterizations of the model through simple ini file.
Release Date: July 31, 2019
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_26_Build_213/).
Build-207
The COPASI team announces the immediate availability of the stable release COPASI 4.25 (Build 207).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This release has several new features:
* Graphical User Interface (CopasiUI)
* Added capability to load and save model parameter sets from files.
* Moiety results are now displayed according to the framework, i.e. in amount units or particle numbers.
* Added default report moiety task
* Advanced rarely used method parameters are no hidden if they are at default setting. The user can change this behavior through the preference dialog.
* Combine archive are can now be opened via drag and drop like all other supported formats.
* Added additional plot type supporting banded graphs.
* Added the capability to open files directly from an URL under the file menu.
* Added Lyapunov exponents to the selectable result in the object selection widget.
* Command-line (CopasiSE)
* Added option to convert the model reactions to irreversible
* Added option to specify the task to be executed
* Added option to override the report file name to be used.
* Language Bindings
* The sed-ml and combine archive functionalities are now exposed in the language bindings.
Release Date: March 15, 2019
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_25_Build_207/).
Build-197
The COPASI team announces the immediate availability of the stable release COPASI 4.24 (Build 197).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This is mainly a bug fix release with some GUI improvements:
* Graphical User Interface
* Implemented a new 3d bar graph view of matrixes allowing for better selection of interesting values. The new view also avoids OpenGL issues due to incomplete graphic card support of the OS.
* Improved issue display in the object browser which did not recognize missing expressions for entities of type ODE and occasionally marked missing initial expressions when not required.
* Improved display of advanced method parameters. If advanced parameter usage is indicated in the preferences they will be shown last. If it is not selected non advanced parameters which are not at their value will be shown to inform the user.
* SBML
* Models which explicitely reference Avogadro's number can now be exported to SBML.
Release Date: July 30, 2018
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_24_Build_197/).
Build-184
The COPASI team announces the immediate availability of the stable release COPASI 4.23 (Build 184).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the
[Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This release includes many new features:
New Features
* Graphical User Interface
* Model Merging: COPASI allows to add a second model and to merge its content with the existing one.
* Compartment dimensionality may now be specified as: volume, area, length, or dimensionless.
* Problems (Errors, Warnings) of the model are no marked in the object browser at the problematic entity.
* Enhanced Unit Support for kinetic parameters.
* Import and export of Combine Archive is now supported.
* The full and reduced Jacobian of the current model state are now shown under Model/Mathematical/Matrices.
* Enable copying table and annotated matrix items to the clipboard.
* A warning is now raised when loading an invalid model (i.e: one that does not compile) and the problematic
entity is marked in the browser pane.
* Added ability to add COPASI version, current date/time, first name, last name, email and organization as
well as line breaks to a reports.
* Allow for the selection of matrices in Object Browser expert mode.
* Plots can be associated with tasks similar to the existing report association
* The direct dependencies, i.e, the objects which are directly effected by changes or removal of an
entity are now displayed on all modeling entities.
* Simulation Engine
* COPASI supports Stochastic Differential Equations (SDEs). It is possible to add noise to reactions and
entities (compartments, species, and global quantities) determined by ODEs.
Release Date: April 18, 2018
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_23_Build_184/).
Build-170
The COPASI team announces the immediate availability of the stable release COPASI 4.22 (Build 170).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the
[Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. The main improvement in this release is the significantly increased performance.
Release Date: November 10, 2017
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_22_Build_170/).
Build-166
The COPASI team announces the immediate availability of the stable release COPASI 4.21 (Build 166).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the
[Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. The main improvement in this release is the significantly increased performance.
Release Date: October 09, 2017
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_21_Build_166/).
Build-158
The COPASI team announces the immediate availability of the stable release COPASI 4.20 (Build 158).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This is mainly a bug fix release and with the following new features:
* Graphical User Interface (CopasiUI)
* It is now possible to export the rendered mathematical expressions to a PDF document.
* The application window remembers the size of the window and the with of the left browser pane to avoid frequent adjustment by the user.
* Plots can now be activated and deactivated in the plot itself.
* When an experimental data file is not found at the expected location COPASI allows now specify a new location by opening a file open dialog.
* Simulation Engine
* The Avogadro symbol can now be used in user defined functions.
Release Date: July 31, 2017
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_20_Build_158/).
Build-140
The COPASI team announces the immediate availability of the stable release COPASI 4.19 (Build 140).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This is a bug fix release which fixes an access violation crash.
Release Date: January 12, 2017
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_19_Build_140/).
Build-136
The COPASI team announces the immediate availability of the stable release COPASI 4.18 (Build 136).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge. This is a bug fix release which fixes an access violation crash.
Release Date: November 28, 2016
More information can be found in the [changelog](http://copasi.org/Support/Change_History/COPASI_4_18_Build_136/).
Build-135
The COPASI team announces the immediate availability of the stable
release COPASI 4.17 (Build 135).
A new release of COPASI has been made available. Please visit our [free download](http://copasi.org/Download/) page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://copasi.org/Download/License/), which is an [OSI](http://www.opensource.org/) approved license. This license allows non-commercial and commercial use free of charge.
Release Date: November 21, 2016
New Features since COPASI 4.16 (Build 104)
- Graphical User Interface (CopasiUI)
- Support for user defined units.
- Extended unit selection options for time, volume and quantity of the model. These extended options include user defined units.
- Unit support for Global Quantities.
- Undo and redo support for all model changes.
- Improved user interface to method parameters.
- Selection of matrix and vector elements by name in addition to the index for plots, reports, and in mathematical expressions.
- Support for contour plots.
- Sorting off all analysis result tables is now enabled where appropriate.
- The MCA results contain now information whether the summation theorems are violated or not allowing the user to easily evaluate the numerical accuracy of the result.
- It is now possible to the select the units of the rate low for a reaction as either amount per time or concentration per time. If concentration per time is selected and the reaction participates in multiple compartments the scaling compartment can be selected.
- Simulation Engine
- Added support for arbitrary events to the Stochastic Direct Method.
- New hybrid simulation algorithm: (Hybrid RK-45) which supports arbitrary discrete events and user defined ODEs. Additionally, the user can specify which reaction are treated continuously and which are treated discretely. This algorithm passes the SBML semantic test suite and stochastic suite.
- It is now possible to report or plot only the internal steps taken by the integration algorithm in the trajectory task.
- SBML
- Full support for SBML Level 3.1 event semantics
- Import and export of unit definitions.
- SBOTerms are no imported and displayed as part of the MIRIAM annotation. On export a the first SBOTerm of the MIRIAM annotation is used if the SBML entity does not have the SBOTerm set.
A list of resolved issues can be found in the
[changelog]({{ site.baseurl }}/Support/Change_History/COPASI_4_17_Build_135/).
Build-104
New Features since COPASI 4.15 (Build 95)
- Graphical User Interface (CopasiUI)
- The copy to next feature in the Experimental data description
dialog is now able to handle the situation were the target
experiment has less columns than the copied one.
- Simulation Engine
- The Gamma distribution and the Poisson distribution are now
accessible in mathematical expressions and exported to SBML.
- SBML
- COPASI now exports the SBML L1V1 legacy format.
A list of resolved issues can be found in the
[changelog](http://copasi.org/Support/Change_History/COPASI_4_16_Build_104/).
Build-95
Build-89
A new release of [COPASI](http://www.copasi.org) has been made available. Please visit our free download page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://opensource.org/licenses/Artistic-2.0), which is an OSI approved license. This license allows non-commercial and commercial use free of charge. This release is mainly a bug fix release which increases the stability and usability of COPASI. It therefore contains only few new features.
Release Date: Oct. 10, 2014
New Features since COPASI 4.13 (Build 87)
Simulation Engine
- Added gamma distribution to the option for the sampling distributions for the scan task.
A list of resolved issues can be found in the [changelog](http://www.copasi.org/tiki-index.php?page=Build89Changelog).
Build-87
A new release of [COPASI](http://www.copasi.org) has been made available. Please visit our free download page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://opensource.org/licenses/Artistic-2.0), which is an OSI approved license. This license allows non-commercial and commercial use free of charge. This release is mainly a bug fix release which increases the stability and usability of COPASI. It therefore contains only few new features.
Release Date: Aug. 14, 2014
New Features since COPASI 4.12 (Build 81)
Graphical User Interface (CopasiUI)
- Copy feature implemented for reports and plots
Simulation Engine
- The parameter task can now save multiple parameter set for each fitted experiment.
A list of resolved issues can be found in the [changelog](http://www.copasi.org/tiki-index.php?page=Build87Changelog).
Build-81
A new release of [COPASI](http://www.copasi.org) has been made available. Please visit our free download page to retrieve this latest development release. Please note this version is released under the [Artistic License 2.0](http://opensource.org/licenses/Artistic-2.0), which is an OSI approved license. This license allows non-commercial and commercial use free of charge. This release is mainly a bug fix release which increases the stability and usability of COPASI. It therefore contains only few new features.
Release Date: Apr. 18, 2014
New Features since COPASI 4.11 (Build 65)
Graphical User Interface (CopasiUI)
- Model Parameter Sets
- Import and Export of Kinetic Function databases.
- Improved Network Diagrams
- Copy functionality for model entities (compartment, species, reactions, functions, etc.)
- Improved child window management under the window menu entry.
- Histograms are now displaying consistently scaled bars (% of total number of recorded values)
- Fixed problem where MIRIAM hyperlinks where not correctly generated for some old style resource identifiers.
Simulation Engine
- New optimization algorithm: Scatter Search
- New MCA algorithm (Smallbone)
- Continuation on simultaneous events
SED-ML
- Implemented SED-ML support
Source package
- CMake based build system
A list of resolved issues can be found in the [changelog](http://www.copasi.org/tiki-index.php?page=Build81Changelog).
Build-65
There are no new features in this release. This is a maintenance release, which resolves a list of issue present in previous releases. A list of resolved issues can be found in the [changelog](http://www.copasi.org/tiki-index.php?page=Build64Changelog).
Note added Nov 4, 2013: We found a problem with the binaries of build 64 and have corrected this with Build 65. There is no difference in the source code so these two have exactly the same version (4.11), the build number is the only distinction between the two. If you have found problems importing SBML with Build 64 then please upgrade to Build 65! If you have not yet downloaded, then just use Build 65.
Build-64
Release Date: May 16, 2013
New Features since COPASI 4.9.45 (Development)
Graphical User Interface (CopasiUI)
- Impproved the cross section task interface to be more intuitive.
SBML
- Enabled export of models which use initial values of species, compartments or global quantities in mathematical expression.
A list of resolved issues can be found in the [changelog](http://www.copasi.org/tiki-index.php?page=Build55Changelog).
Build-35-Release
A new stable release of [COPASI](http://www.copasi.org) has been made available. Please visit our free download page to retrieve this latest stable release. Please note this version is released under the [Artistic License 2.0](http://opensource.org/licenses/Artistic-2.0), which is an OSI approved license. This license allows non-commercial and commercial use free of charge. This release is mainly a bug fix release which increases the stability and usability of COPASI. It therefore contains only few new features.
New features since the previous stable release:
Graphical User Interface (CopasiUI)
Added plots and reports for parameter scans to the output assistant.
Only applicable plots and reports are shown in the output assistant by default.
Simulation Engine
Time Scale Separation Analysis can now handle multi compartment models.
The Time Scale Separation Analysis can now be applied to the full as well as the reduced model.
It is now possible to calculate the sensitivities of Eigen values.
Add kinetic function Bi (irreversible) to the builtin functions.
A list of resolved issues can be found in the [changelog](http://www.copasi.org/tiki-index.php?page=Build35Changelog). for this release
Build-34-Release
The COPASI team announces the immediate availability of the stable release COPASI 4.7 (Build 34).
Build-33-Release
The COPASI team announces the immediate availability of the development release COPASI 4.6.33 (development).
Build-32-Release
The COPASI team announces the immediate availability of the stable release COPASI 4.6 (Build 32).
Build-31-Release
The COPASI team announces the immediate availability of the development release COPASI 4.5.31 (development).
Build-30-Release
A new stable release COPASI 4.5 (Build 30) is now available.
Build-29-Release
The COPASI team announces the immediate availability of the development release COPASI 4.4.29 (development).
Build-28-Release
The COPASI team announces the immediate availability of the development release COPASI 4.4.28 (development).
Build-27-Release
The COPASI team announces the immediate availability of the development release COPASI 4.4.27(development).
Build-26-Release
A new stable release COPASI 4.4 (Build 26) is now available.
Release-Build-25
A new stable release COPASI 4.3 (Build 25) is now available.
Build-24
The COPASI team announces the immediate availability of the development release COPASI 4.2.24 (development).
Build-23
The COPASI team announces the immediate availability of the development release COPASI 4.2.23 (development).
Build-22
The COPASI team announces the immediate availability of COPASI 4.2 (Build 22).
Build-21
The COPASI team announces the immediate availability of COPASI 4.1 (Build 21).
Build-20
The COPASI team announces the immediate availability of COPASI 4.0.20 (development).
Build-19
The COPASI team announces the immediate availability of COPASI 4.0.19 (development).
Release-4-0-18
The COPASI team announces the immediate availability of COPASI 4.0.18.
Build-17
The COPASI team announces the immediate availability of COPASI 4.0.17 (Release Candidate 1).