Scipion-em-cryosparc2

Latest version: v4.1.5

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4.1.5

Compatibility with cryoSPARC v4.6

4.1.4

Compatibility with cryoSPARC v4.5.3

4.1.2

fixed: Installation Hot fix

4.1.1

Compatibility with cryoSPARC v4.5.1
Registering flex particles
Integration with FlexUtils plugin

4.1.0

Tolerating deletion of projects within CS as well as their folders in the file system
Add new protocols:
* **3D Flex Data Prep**: Prepares particles for use in 3DFlex training and reconstruction. At the same way, Takes in a consensus (rigid) refinement density map, plus optionally a segmentation and generates a tetrahedral mesh for 3DFlex.
* **3D Flex Mesh Prep**: Takes in a consensus (rigid) refinement density map, plus optionally a segmentation and generates a tetrahedral mesh for 3DFlex. See Mesh Generation below.
* **3D Flex Training**: Uses a mesh and prepared particles (at a downsampled resolution) to train a 3DFlex model. Parameters control the number of latent dimensions, size of the model, and training hyperparameters. This job outputs checkpoints during training.
* **3D Flex Reconstruction**: Takes in a checkpoint from training as well as prepared high-resolution particles and performs high-resolution refinement using L-BFGS under the 3DFlex model. This is the stage at which improvements to density in high-res regions are computed. Outputs two half-maps that can be used for FSC validation, sharpening, and other downstream tasks.
Allowing Scipion to import coordinates

4.0.11

Compatibility with cryoSPARC v4.4.1 + Patch

Dec 22, 2023 - **v4.0.10**
Compatibility with cryoSPARC v4.4.1

Add new protocols:
* **3D Variability Analysis**: Protocol to compute the principle modes of variability with a dataset of aligned particles
* **3D Variability Display**: Protocol to create various versions of a 3D variability result that can be used for display
* **Blob Picker**: Automatically picks particles by searching for Gaussian signals.
* **Patch CTF Estimation**: Patch-based CTF estimation automatically estimates defocus variation for tilted, bent, deformed samples and is accurate for all particle sizes and types including flexible and membrane proteins.

Nov 17, 2023 - **v4.0.9**
Compatibility with cryoSPARC v4.4.0
Handling aborted protocols/jobs

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