Slim-TPCA package is a python package which requires python version higher than 3.7 to work. Slim-TPCA has been optimised based on the TPCA method published in 2018. By using fewer temperature points, Slim-TPCA can reduce the volume of samples required, eliminate the batch effect in multiplex mass spectrometry experiments, and greatly shorten the calculation time required. In the Slim-TPCA package, users can perform data pre-processing, graph ROC plots to determine the ability of the data to predict protein interactions, calculate the TPCA signatures of the complexes and dynamic modulations of the complexes.