Microhapdb

Latest version: v0.11

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0.8

Added
- 25 marker definitions from Sun et al 2020 (see 87).
- 23 marker definitions from Jin et al 2020 (see 89).
- 20 marker definitions from Kureshi et al 2020 (see 90).
- GRCh38 offsets to `microhapdb marker --format=offsets` (see 92).
- 59 marker definitions from Wu et al 2021 (see 96).
- 22 marker definitions from Fan et al 2022 (see 97).
- New sphinx-based documentation suite hosted on ReadTheDocs.org (see 101).

Changed
- Minor improvements to database build and corresponding documentation (see 88).
- Major overhaul of the Python API (see 99).

Fixed
- Bug with dereferencing IDs and ID cross-references (see 99, 100).

0.7

Added
- Markers and population frequency data (1000 Genomes and proprietary) for the mMHseq 90-plex panel (see 68).
- New `--extend-mode` option when displaying markers in `fasta` or `detail` mode (see 72).
- New options for preparing MicroHapDB data for import into MicroHapulator (see 80).
- New option for preparing MicroHapDB frequency data for import into probgen tools like LRMix Studio or EuroForMix (see 82).

Changed
- Support for pandas>=1.2 added, support for Python 3.6 dropped (see 74).
- The `--marker` and `--population` flags for `microhapdb frequency` now support multiple arguments (see 81).

Fixed
- Error message when detail view is requested for a marker without frequency information (see 67).
- Problematic haplotype frequencies for 4 mMHseq markers including SNPs whose rsIDs are not present in the original 1KGP data (see 73).

0.6

Added
- Added F_ST (fixation index) to the markers table (see 59, 62, 63).
- Added the ability to swap out population-specific Ae values for the default 26-population average (see 63).
- Support for GRCh37 (see 64).

Changed
- Various updates to documentation (see 60).
- Cosmetic updates to "marker --detail" (see 61).
- Refactoring of database build: cleanup using Pandas, reorganization for GRCh37 support (see 62, 64).

0.5

Added
- Added 10 marker definitions from Voskoboinik et al 2018 (see 47).
- Added 118 marker definitions from de la Puente, Phillips, et al 2020 (see 49, 54).
- Added microhap frequency estimates for 26 global populations to all markers from the 1000 Genomes Project Phase 3 dat (see 55).
- Added I_n (informativeness for assignment) scores to each marker (see 56).

Fixed
- Removed duplicate entry for marker `mh11CP-004` (see 46).
- Corrected marker name from `mh05KK-058` to `mh15KK-058` (see 46).
- Corrected erroneous rsID assignments for van der Gaag 2018 markers (see 46).

Changed
- 26 global populations from the 1000 Genomes Project migrated from ALFRED data source to a dedicated 1KGP data source (see 45).
- Dropped Travis CI configuration (see 47).
- Changed default delta from 25 to 10 and default minlength from 250 to 80 (see 52).

0.4.3

Fixed
- Squashed a bug with package data not being installed correctly.

0.4.2

Changed
- Some aspects of panel design and definition migrated from MicroHapulator to MicroHapDB (see 34, 35).
- Minor changes to `TargetAmplicon` class to support MicroHapulator (see 36).

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