Mikado

Latest version: v2.3.4

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0.23.1

Changes:

- Stats is now much faster and lighter, as objects are discarded upon analysis, not kept around for the whole run duration
- Pick now preferentially outputs only one ORF per transcript, behaviour regulated by pick/output_format/report_all_orfs
- BugFix for the detection of fragments during pick

0.23.0

New features:

- Added a converter for (GTF <=> GFF3) > BED12 conversions in mikado.py util convert
- Now it is possible to provide a predefined malus/bonus to transcripts according to their sources using the following syntax in the configuration file:

pick:
source_score:
source1: score1
source2: score
...

It is generally *not* advised to use such an option unless the user really wants to emphasize or penalise a particular set of transcripts, eg. those coming from PacBio data.

0.22.0

Transitioned the XML parser to the experimental Bio.SearchIO module, which uses internally C-level APIs and is therefore twice as fast than the canonical implementation. This required some rewriting at the class level in Mikado and a cloning of the original class to make it a proper iterative class.
Moreover, now requirements for the scoring can accept also eg boolean values.

0.21.0

Major changes for this release:

- Trim is now functioning
- ORFs from transdecoder are treated correctly - even truncated and internal ones. No more faux UTRs!
- Changes in the DB structure to accomodate the ORF information - note, this means that the databases have to be regenerated

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