API `issubtype`:
* Fix for Union: now `issubtype(Union[list, tuple], typing.Sequence) == True`
* Fix `None` as an alias of `type(None)`
* Support TypeVar checking, while `issubtype(TypeVar("T1"), TypeVar("T2")) == typing_utils.unknown`
* Fix for Callable: `Callable[[int], str]` won't raise an exception anymore.