Filtus

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NEW FEATURES:
* This is test release after reworking several modules, including many GUI improvements and minor changes. More information to come.

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BUG FIX:
* Database module was partly broken, should be ok now.

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NEW FEATURES:
* Added example in the "de novo" help page. Uses the file "trioHG002_22X.vcf" in the "testfiles" folder, containing variants on chromosome 22 and X from a Genome-in-a-bottle trio.

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OTHER:
* Increased default font size
* Bug fixes and clean-ups.

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NEW FEATURES:
* Relevant for variant files annotated by VEP: If the INFO field contains a CSQ field, Filtus now offers to split this intelligently, using the format indicated in the preamble of the file. To activate this feature, first indicate "Split as INFO" in the input dialog, and then check "and split CSQ". If consequences for several transcripts/alleles are included for a variant, only the first is used. It is therefore recommended to run VEP with the "--pick" option, which selects only one consequence.

BUG FIXES:
* Better error handling of malformed variant files.

* Fixed bug causing Filtus to crash when trying to run PLINK homozygosity without PLINK being installed.

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NEW FEATURES:
* Improved handling of VCF files. Several samples in one file are now allowed.

* Rewritten and simplified the input settings dialog. In particular, variants are (for now, may extend this later)
always defined by chromosome and position. The names of the columns containing this info must always be indicated.