- improved reduction step performance (fasta2homozygous.py)
- no sorting - greatly improves performance on large and fragmented genomes
- removed `-S / --sortopt` parameter
- no BLAT - unable to multi-thread BLAT, thus relying on LAST completely
- global alignment `-T 1`, instead of local - speed-up and less permissive (more accurate) reduction
- enabled [multi-threading in LAST from v693](http://last.cbrc.jp/last/index.cgi/rev/4174fdbdb9a1)
- no temp files
- all is processed through pipes
- removed unnecessary maf-convert, gzip and file parsing
- code polished