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5.3rc03

5.3rc02

5.3rc01

We are happy to announce the [Insight Toolkit (ITK)](https://itk.org) 5.3 Release Candidate 1 is available for testing! :tada: ITK is an open-source, cross-platform toolkit for N-dimensional scientific image processing, segmentation, and registration.

ITK 5.3 is a feature release that accelerates performance, provides new segmentation and shape analysis algorithms, and makes over 200 more improvements.

Release Candidate 1 highlights performance improvements. For deformable image registration, b-spline sampling was improved by ~30%. Multi-threading in Python was improved by adding Threading Building Blocks ([oneTBB](https://github.com/oneapi-src/oneTBB)) to the cross-platform binaries, which [improves multi-threaded parallelism](https://github.com/InsightSoftwareConsortium/ITK/releases/tag/v5.0a02) by ~5-10%. Compression time with zlib, used by common medical imaging file formats like NIFTI, NRRD, or MetaImage, was dramatically reduced through migration to [zlib-ng](https://github.com/zlib-ng/zlib-ng).


![](https://i.imgur.com/tQl8niW.png)


| name | description | zlib duration \[ms\] | zlib C.Ratio | zlib-ng duration \[ms\] | zlib-ng C.Ratio | zlib-ng Speed-up | zlib-ng C. Ratio improvement |
| ----------------- | ---------------- | ---------------- | ------------ | ------------------- | --------------- | ---------------- | ---------------------------- |
| wbPET.mha | whole body PET | 672 | 9.7% | 661 | 9.3% | 2% | 4% |
| mra.nrrd | MR angiography | 1300 | 49.0% | 1097 | 49.1% | 19% | 0% |
| CBCT.nrrd | ConeBeam CT | 11281 | 42.5% | 9486 | 41.3% | 19% | 3% |
| input.nii | brain MRI | 4818 | 57.6% | 3353 | 57.4% | 44% | 0% |
| scan7.mha | mouse ultrasound | 5939 | 45.4% | 4694 | 46.2% | 27% | \-2% |
| TBR5\_clinpet.nii | label map | 782 | 0.5% | 91 | 0.5% | 759% | \-2% |
| WhiteMatter.nii | label map | 185 | 5.6% | 76 | 5.8% | 143% | \-4% |
| **Average** | | | | | | **145\%** | **0\%** |

*Comparison of image compression with traditional `zlib` library and the new `zlib-ng` replacement introduced with ITK 5.3 using the default compression level.*

Download
--------

**Python Packages**

Install [ITK Python packages](https://itkpythonpackage.readthedocs.io/en/latest/Quick_start_guide.html) with:


pip install --upgrade --pre itk



**Library Sources**

- [InsightToolkit-5.3rc01.tar.gz](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.3rc01/InsightToolkit-5.3rc01.tar.gz)
- [InsightToolkit-5.3rc01.zip](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.3rc01/InsightToolkit-5.3rc01.zip)

**Testing Data**

Unpack optional testing data in the same directory where the Library Source is unpacked.

- [InsightData-5.3rc01.tar.gz](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.3rc01/InsightData-5.3rc01.tar.gz)
- [InsightData-5.3rc01.zip](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.3rc01/InsightData-5.3rc01.zip)

**Checksums**

- [MD5SUMS](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.3rc01/MD5SUMS)
- [SHA512SUMS](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.3rc01/SHA512SUMS)

Features
--------

Python

- Python packages now include oneTBB support for improved performance.
- Following CPython's deprecation schedule Python 3.6 is no longer supported.
- Initial Python wrapping is available for the Video modules.
- `TransformToDisplacementField` is now available in Python.

C++

- C++14 is now required.
- The minimum CMake version required is now 3.16.3.
- New functions: `MakePoint`, `MakeVector`, `MakeIndex`, `MakeSize`.

New filter

- `itk::TransformGeometryImageFilter`: applies a rigid transform to an `Image`'s metadata.

Remote module updates

New remote modules:

- [HASI](https://github.com/KitwareMedical/HASI): High-Throughput Applications for Skeletal Imaging
- [ITKGrowCut](https://github.com/InsightSoftwareConsortium/ITKGrowCut): segments a 3D image from user-provided foreground and background seeds

Updated modules: *AdaptiveDenoising*, *AnisotropicDiffusionLBR*, *BSplineGradient*, *BoneEnhancement*, *BoneMorphometry*, *Cuberille*, *GrowCut*, *HASI*, *HigherOrderAccurateGradient*, *IOFDF*, *IOScanco*, *IsotropicWavelets*, *MinimalPathExtraction*, *Montage*, *MorphologicalContourInterpolation*, *RTK*, *SimpleITKFilters*, *SkullStrip*, *SplitComponents*, *Strain*, *TextureFeatures*, *Thickness3D*, *TotalVariation*, *TubeTK*, and *Ultrasound*.


Third party library updates

- gdcm
- niftilib
- zlib migrated to zlib-ng
- hdf5
- kwsys
- metaio
- googletest
- vxl

Congratulations

Congratulations and **thank you** to everyone who contributed to this release.

Of the *32 authors* who contributed since v5.2.0, we would like to specially recognize the new contributors:

*Pranjal Sahu, Darren Thompson, Tomoyuki SADAKANE, Oleksandr Zavalistyi, Jose Tascon, Kian Weimer, Michael Kuczynski, Ebrahim Ebrahim, and Philip Cook.*


What's Next
-----------


We anticipate an additional release candidate following community testing before the 5.3.0 release. The following release candidates will improve related documentation and make further improvements. Please try out the current release candidate, and discuss your experiences at [discourse.itk.org](https://discourse.itk.org). Contribute with pull requests, code reviews, and issue discussions in our [GitHub Organization](https://github.com/InsightSoftwareConsortium).

**Enjoy ITK!**

5.2.1

We are happy to announce the Insight Toolkit (ITK) 5.2.1! :tada: ITK is an open-source, cross-platform toolkit for N-dimensional scientific image processing, segmentation, and registration.


**Python Packages**

Install [ITK Python packages](https://itkpythonpackage.readthedocs.io/en/latest/Quick_start_guide.html) with:


pip install --upgrade itk


**Guide and Textbook**

- [InsightSoftwareGuide-Book1-5.2.1.pdf](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.1/InsightSoftwareGuide-Book1-5.2.1.pdf)
- [InsightSoftwareGuide-Book2-5.2.1.pdf](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.1/InsightSoftwareGuide-Book2-5.2.1.pdf)

**Library Sources**

- [InsightToolkit-5.2.1.tar.gz](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.1/InsightToolkit-5.2.1.tar.gz)
- [InsightToolkit-5.2.1.zip](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.1/InsightToolkit-5.2.1.zip)

**Testing Data**

Unpack optional testing data in the same directory where the Library Source is unpacked.

- [InsightData-5.2.1.tar.gz](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.1/InsightData-5.2.1.tar.gz)
- [InsightData-5.2.1.zip](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.1/InsightData-5.2.1.zip)

**Checksums**

- [MD5SUMS](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.1/MD5SUMS)
- [SHA512SUMS](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.1/SHA512SUMS)


ITK 5.2.1 is a patch release that makes improvements to issues found in the 5.2.0 release. For more details on ITK 5.2, see the [ITK 5.2.0 Release Notes](https://github.com/InsightSoftwareConsortium/ITK/releases/tag/v5.2.0).

This release addresses various issues like improved combination of `itk`'s native thread pool with Python's `multiprocessing` module in contexts like [MONAI](https://monai.io/) and [Dask](https://dask.org/). Other improvements include more robust label map statistic computation, expanded Python support for additional datatypes, fixes for tube spatial objects when processing with the [TubeTK](https://github.com/InsightSoftwareConsortium/ITKTubeTK) module, support for GCC 11, and compatibility with the C\+\+20 and C\+\+23 standards. A detailed list can be found in the changelog below.

What's Next
-----------

Join us in the creation of advanced, open source scientific image analysis tools. Take part in the community discussion at [discourse.itk.org](https://discourse.itk.org). Contribute with pull requests, code reviews, and issue discussions in our [GitHub Organization](https://github.com/InsightSoftwareConsortium).

The first release candidate for ITK 5.3, the next feature release, is anticipated in September.

**Enjoy ITK!**

5.2

==========================================

We are happy to announce the [Insight Toolkit (ITK)](https://itk.org) 5.2 Release Candidate 1 is available for testing! :tada: ITK is an open-source, cross-platform toolkit for N-dimensional scientific image processing, segmentation, and registration.

ITK 5.2 is a feature release that improves and extends interfaces to deep learning, artificial intelligence (AI) libraries, with an emphasis on [Project MONAI](https://monai.io), the Medical Open Network for AI. ITK 5.2 feature highlights include functional filter support for PyTorch tensors, Python dictionary interfaces to `itk.Image` metadata, NumPy-based pixel indexing, 4D Python image support, and improved multi-component image support.

Downloads
---------

**Python Packages**

Install [ITK pre-release binary Python packages](https://itkpythonpackage.readthedocs.io/en/latest/Quick_start_guide.html) with:


pip install --upgrade --pre itk


**Library Sources**

- [InsightToolkit-5.2rc01.tar.gz](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2rc01/InsightToolkit-5.2rc01.tar.gz)
- [InsightToolkit-5.2rc01.zip](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2rc01/InsightToolkit-5.2rc01.zip)

**Testing Data**

Unpack optional testing data in the same directory where the Library Source is unpacked.

- [InsightData-5.2rc01.tar.gz](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2rc01/InsightData-5.2rc01.tar.gz)
- [InsightData-5.2rc01.zip](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2rc01/InsightData-5.2rc01.zip)

**Checksums**

- [MD5SUMS](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2rc01/MD5SUMS)
- [SHA512SUMS](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2rc01/SHA512SUMS)


Features
--------

MONAI-compatible `itk.Image` metadata dict and NumPy-indexing pixel set/get Python interfaces.


print(image['0008|0008'])
image['origin'] = [4.0, 2.0, 2.0]



or a dictionary can be retrieved with:


meta_dict = dict(image)

For example:


In [3]: dict(image)
Out[3]:
{'0008|0005': 'ISO IR 100',
'0008|0008': 'ORIGINAL\\PRIMARY\\AXIAL',
'0008|0016': '1.2.840.10008.5.1.4.1.1.2',
'0008|0018': '1.3.12.2.1107.5.8.99.484849.834848.79844848.2001082217554549',
'0008|0020': '20010822',


For non-string keys, they are passed to a NumPy array view so array views can be set and get with NumPy indexing syntax, e.g.


In [6]: image[0,:2,4] = [5,5]

In [7]: image[0,:4,4:6]
Out[7]:
NDArrayITKBase([[ 5, -997],
[ 5, -1003],
[ -993, -999],
[ -996, -994]], dtype=int16)


Provides a Python dictionary interface to image metadata, keys are
MetaDataDictionary entries along with 'origin', 'spacing', and
'direction' keys. The later reverse their order to be consistent with
the NumPy array index order resulting from array views of the image.

Python functional filter support for PyTorch tensors

Similar to functional [filter support for NumPy `ndarray`-like images, i.e. a `numpy.ndarray`, Dask Array or `xarray.DataArray`s](https://github.com/InsightSoftwareConsortium/ITK/releases/tag/v5.1.0), all `itk.Image` filters now support execution on PyTorch `Tensor`'s.

For example:


import itk
import torch
import numpy as np

a = np.random.rand(50,50)
t = torch.from_numpy(a)
r = itk.median_image_filter(t)


Pythonic enhancements

`itk.Image` now provides an `astype()` method for casting to a NumPy `dtype` or `itk` pixel type.

In addition to an image filename or an image filename stack in a Python list, pass in a directory to `itk.imread` containing a DICOM series to obtain the appropriately ordered 3D image.

`itk.vtk_image_from_image()` and `itk.image_from_vtk_image()` for working with [VTK](https://vtk.org).

We now generate `.pyi` Python interface files, providing better feedback in integrated development environments (IDE)'s like PyCharm.

Python code was modernized for Python 3.6, including some typehints. We now use the [`black`](https://github.com/psf/black) Python style.

An `itk.set_nthreads()` convenience function is available to set the default number of threads. Support is now available for use in the Python `multiprocessing` module.

Python package layout improvements

Python support module organization has been organized into the `itk.support.*` package.

Python development was added for multi-config CMake generators, e.g. Visual Studio or multi-config Ninja, with the limitation that it only works with the most recently built configuration. When developing ITK Python wrapping or ITK remote modules, copy the `WrapITK.pth` build tree file to your virtual environment or conda environment `site-packages` to experiment with the wrapping.

Python package advances

Improved `VectorImage` and multi-component image support is available in the ITK Python packages.

NumPy is now a required package dependency.

Python packages are now built with interprodedural optimizations (IPO). Linux Python packages are built with the `manylinux2014` toolchain.

Python packages are available for Python 3.6 to 3.9. Following CPython deprecation schedule, this is the last release to support Python 3.6.

C++ interface improvements

A new `itk::FunctionCommand` class is available, an `itk::Command` subclass that calls a `std::function` objects or lambda functions.

New `itk::ReadImage`, `itk::WriteImage` convenience functions are available for reading and writing image files with minimal code.

An `itk::Image` now supports `operator==` and `operator!=`.


A new `itk::TernaryGeneratorImageFilter` class is now available.

Third party library updates

Updates were made for the third party libraries:

* GDCM
* HDF5
* double-conversion
* pygccxml
* castxml
* swig
* VXL
* KWIML
* KWSys
* MetaIO
* cuFFTW


Remote Module Updates

We added a new [adaptive denoising](https://github.com/ntustison/ITKAdaptiveDenoising) remote module.

Many remote modules were updated: *AdaptiveDenoising*, *AnalyzeObjectLabelMap*, *AnisotropicDiffusionLBR*, *BSplineGradient*, *BioCell*, *BoneEnhancement*, *BoneMorphometry*, *Cuberille*, *FixedPointInverseDisplacementField*, *GenericLabelInterpolator*, *HigherOrderAccurateGradient*, *IOFDF*, *IOMeshSTL*, *IOOpenSlide*, *IOScanco*, *IOTransformDCMTK*, *IsotropicWavelets*, *LabelErodeDilate*, *LesionSizingToolkit*, *MGHIO*, *MeshNoise*, *MinimalPathExtraction*, *Montage*, *MorphologicalContourInterpolation*, *MultipleImageIterator*, *ParabolicMorphology*, *PerformanceBenchmarking*, *PhaseSymmetry*, *PolarTransform*, *PrincipalComponentsAnalysis*, *RLEImage*, *RTK*, *SCIFIO*, *SimpleITKFilters*, *SkullStrip*, *SmoothingRecursiveYvvGaussianFilter*, *SplitComponents*, *Strain*, *SubdivisionQuadEdgeMeshFilter*, *TextureFeatures*, *Thickness3D*, *TotalVariation*, *TubeTK*, *TwoProjectionRegistration*, and *VariationalRegistration*.
Their updates are included in the detailed changelog below.

Support for cross-platform C++ testing, Python package generation, and PyPI deployment with GitHub Actions was added to almost all remote modules.


Test coverage and bug fixes

A multitude of test code coverage improvements were made -- our code coverage is [now 89.86%](https://open.cdash.org/index.php?project=Insight) with 126,590 lines tested.

Many more bug fixes and improvements have been made. For details, see the changelog below.

Congratulations

Congratulations and **thank you** to everyone who contributed to this release.

Of the *51 authors* who contributed since v5.1.0, we would like to specially recognize the new contributors:

Horea Christian, Baptiste Depalle, David Thompson, Pierre Wargnier, Darren Thompson, Sebastien Brousmiche, Alexander Burchardt, Marco Nolden, Michael Kuczynski, MrTzschr, Bernhard M. Wiedemann, Charles Garraud, Lee Newberg, Bryn Lloyd, Gregory Lee, justbennet, Kenji Tsumura, Zhiyuan Liu, Jonathan Daniel, Moritz Schaar, Atri Bhattacharya, and Mon-ius.


What's Next
-----------


We anticipate at least one more release candidate following community testing before the 5.2.0 release. The following release candidates will improve related documentation and make further improvements. Please try out the current release candidate, and discuss your experiences at [discourse.itk.org](https://discourse.itk.org). Contribute with pull requests, code reviews, and issue discussions in our [GitHub Organization](https://github.com/InsightSoftwareConsortium).

**Enjoy ITK!**

5.2.0

=======================

We are happy to announce the release of [Insight Toolkit (ITK)](https://itk.org) 5.2.0! :tada: ITK is an open-source, cross-platform toolkit for N-dimensional scientific image processing, segmentation, and registration.

ITK 5.2 is a feature release that improves and extends interfaces to deep learning, artificial intelligence (AI) libraries, with an emphasis on [Project MONAI](https://monai.io), the Medical Open Network for AI. ITK 5.2 feature highlights include functional filter support for PyTorch tensors, Python dictionary interfaces to `itk.Image` metadata, NumPy-based pixel indexing, 4D Python image support, and improved multi-component image support.

Changes from Release Candidate 3 include an updated [Python Quick Start Guide](https://itkpythonpackage.readthedocs.io/en/master/Quick_start_guide.html) and many improvements to the [ITK Sphinx Examples](https://itk.org/ITKExamples/).

Experimental pip-installable Python packages are available for ARMv8 on macOS for the Apple M1 Silicon processor, and Linux, also known as aarch64. For a scientific computing environment on these platforms, we recommend [mini-forge](https://github.com/conda-forge/miniforge).

The pip-installable Python packages work with conda across all platforms. We are working to add native conda-forge packages in a future release.

All Pythonic, functional filter interfaces have type annotations with common, standard types along with `numpy.typing.ArrayLike` and `itk.support.types.ImageLike`.

Many other improvements were made since RC 3 based on community feedback. A full list can be found in the Changelog below.

Downloads
---------

**Python Packages**

Install [ITK Python packages](https://itkpythonpackage.readthedocs.io/en/latest/Quick_start_guide.html) with:


pip install --upgrade itk



**Guide and Textbook**

- [InsightSoftwareGuide-Book1-5.2.0.pdf](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.0/InsightSoftwareGuide-Book1-5.2.0.pdf)
- [InsightSoftwareGuide-Book2-5.2.0.pdf](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.0/InsightSoftwareGuide-Book2-5.2.0.pdf)

**Library Sources**

- [InsightToolkit-5.2.0.tar.gz](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.0/InsightToolkit-5.2.0.tar.gz)
- [InsightToolkit-5.2.0.zip](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.0/InsightToolkit-5.2.0.zip)

**Testing Data**

Unpack optional testing data in the same directory where the Library Source is unpacked.

- [InsightData-5.2.0.tar.gz](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.0/InsightData-5.2.0.tar.gz)
- [InsightData-5.2.0.zip](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.0/InsightData-5.2.0.zip)

**Checksums**

- [MD5SUMS](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.0/MD5SUMS)
- [SHA512SUMS](https://github.com/InsightSoftwareConsortium/ITK/releases/download/v5.2.0/SHA512SUMS)




Features
--------

MONAI-compatible `itk.Image` metadata dict and NumPy-indexing pixel set/get Python interfaces.


print(image['0008|0008'])
image['origin'] = [4.0, 2.0, 2.0]



or a dictionary can be retrieved with:


meta_dict = dict(image)

For example:


In [3]: dict(image)
Out[3]:
{'0008|0005': 'ISO IR 100',
'0008|0008': 'ORIGINAL\\PRIMARY\\AXIAL',
'0008|0016': '1.2.840.10008.5.1.4.1.1.2',
'0008|0018': '1.3.12.2.1107.5.8.99.484849.834848.79844848.2001082217554549',
'0008|0020': '20010822',


For non-string keys, they are passed to the NumPy array view so array views can be set and get with NumPy indexing syntax, e.g.


In [6]: image[0,:2,4] = [5,5]

In [7]: image[0,:4,4:6]
Out[7]:
NDArrayITKBase([[ 5, -997],
[ 5, -1003],
[ -993, -999],
[ -996, -994]], dtype=int16)


Provides a Python dictionary interface to image metadata, keys are
`MetaDataDictionary` entries along with *'origin'*, *'spacing'*, and
*'direction' keys. The latter reverse their order to be consistent with
the NumPy array index order resulting from array views of the image.

The `itk.xarray_from_image` and `itk.image_from_xarray` functions gained support for transfer of `itk` `MetaDataDictionary` and `xarray` `attrs` along with support for ordering `xarray` `DataArray` `dims`.


Pythonic enhancements

Improved Xarray support was added in the functional [filter support for NumPy `ndarray`-like images, i.e. a `numpy.ndarray`, Dask Array or `xarray.DataArray`s](https://github.com/InsightSoftwareConsortium/ITK/releases/tag/v5.1.0).


`itk.Image` now provides an `astype()` method for casting to a NumPy `dtype` or `itk` pixel type.

In addition to single files or an image stack in a Python list, a directory can be passed to `itk.imread` containing a DICOM series. A spatially ordered 3D image will be obtained.

The conversion functions, `itk.vtk_image_from_image()` and `itk.image_from_vtk_image()` are directly available for working with [VTK](https://vtk.org).

We now generate `.pyi` Python interface files, providing better feedback in integrated development environments (IDE)'s like PyCharm.

Python code was modernized for Python 3.6, including some typehints. We now use the [`black`](https://github.com/psf/black) Python style.

An `itk.set_nthreads()` convenience function is available to set the default number of threads. Support is now available for use in the Python `multiprocessing` module.

In addition to `itk.imread`, `itk.imwrite`, `itk.meshread`, `itk.meshwrite`, spatial transformation IO functions are available, `itk.transformread`, `itk.transformwrite`.

To provide an `itk.ImageIOBase` derived object to read a specific file format, `itk.imread` and `itk.imwrite` gained support for the `imageio` keyword argument.

Python package layout improvements

Python support module organization has been organized into the `itk.support.*` package.

Python development was added for multi-config CMake generators, e.g. Visual Studio or multi-config Ninja, with the limitation that it only works with the most recently built configuration. When developing ITK Python wrapping or ITK remote modules, copy the `WrapITK.pth` build tree file to your virtual environment or conda environment `site-packages` to experiment with the wrapping.

Python package advances

Improved `VectorImage` and multi-component image support is available in the ITK Python packages.

NumPy is now a required package dependency.

Python packages are now built with interprodedural optimizations (IPO). Linux Python packages are built with the `manylinux2014` toolchain.

Binary Python packages are available for ARM on macOS and Linux.

Python packages are available for Python 3.6 to 3.9. Following CPython deprecation schedule, this is the last release to support Python 3.6.

C++ interface improvements

A new `itk::FunctionCommand` class is available, an `itk::Command` subclass that calls `std::function` objects or lambda functions.

New `itk::ReadImage`, `itk::WriteImage` convenience functions are available for reading and writing image files with minimal code.

An `itk::Image` now supports `operator==` and `operator!=`.


A new `itk::TernaryGeneratorImageFilter` class is now available.

Third party library updates

Updates were made for the third party libraries:

* GDCM
* HDF5
* double-conversion
* pygccxml
* castxml
* swig
* VXL
* KWIML
* KWSys
* MetaIO
* cuFFTW


Remote Module Updates

We added a new [adaptive denoising](https://github.com/ntustison/ITKAdaptiveDenoising) remote module.

Many remote modules were updated: *AdaptiveDenoising*, *AnalyzeObjectLabelMap*, *AnisotropicDiffusionLBR*, *BSplineGradient*, *BioCell*, *BoneEnhancement*, *BoneMorphometry*, *Cuberille*, *FixedPointInverseDisplacementField*, *GenericLabelInterpolator*, *HigherOrderAccurateGradient*, *IOFDF*, *IOMeshSTL*, *IOOpenSlide*, *IOScanco*, *IOTransformDCMTK*, *IsotropicWavelets*, *LabelErodeDilate*, *LesionSizingToolkit*, *MGHIO*, *MeshNoise*, *MinimalPathExtraction*, *Montage*, *MorphologicalContourInterpolation*, *MultipleImageIterator*, *ParabolicMorphology*, *PerformanceBenchmarking*, *PhaseSymmetry*, *PolarTransform*, *PrincipalComponentsAnalysis*, *RLEImage*, *RTK*, *SCIFIO*, *SimpleITKFilters*, *SkullStrip*, *SmoothingRecursiveYvvGaussianFilter*, *SplitComponents*, *Strain*, *SubdivisionQuadEdgeMeshFilter*, *TextureFeatures*, *Thickness3D*, *TotalVariation*, *TubeTK*, *TwoProjectionRegistration*, and *VariationalRegistration*.
Their updates are included in the detailed changelog below.

Support for cross-platform C++ testing, Python package generation, and PyPI deployment with GitHub Actions was added to almost all remote modules.


Test coverage and bug fixes

A multitude of test code coverage improvements were made -- our code coverage is [now 90.09%](https://open.cdash.org/index.php?project=Insight) with 127,103 lines tested.

Many more bug fixes and improvements have been made. For details, see the changelog below.

Congratulations

Congratulations and **thank you** to everyone who contributed to this release.

Of the *63 authors* who contributed since v5.1.0, we would like to specially recognize the new contributors:

Horea Christian, Baptiste Depalle, David Thompson, Pierre Wargnier, Darren Thompson, Sebastien Brousmiche, Alexander Burchardt, Marco Nolden, Michael Kuczynski, MrTzschr, Bernhard M. Wiedemann, Charles Garraud, Lee Newberg, Bryn Lloyd, Gregory Lee, justbennet, Kenji Tsumura, Zhiyuan Liu, Jonathan Daniel, Moritz Schaar, Atri Bhattacharya, Mon-ius, Michael Jackson, Tom Birdsong, Alex Domingo, Laurent Malka, Kris Thielemans, Andreas Huber, and Melvin Robinson.

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