Pyrodigal

Latest version: v3.6.3

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3.2.0

Added
- AVX-512 implementation of the SIMD pre-filter.
- Additional support for reading `lz4` and `xz` and `zstd`-compressed input in the CLI.
- Option to change gene finder type in `pyrodigal.cli.main`.

3.1.1

Fixed
- Incorrect unpickling of `GeneFinder` causing crashes with multiprocessing ([46](https://github.com/althonos/pyrodigal/issues/46)).

3.1.0

Added
- Support for Python 3.12.
- `min_mask` argument to `GeneFinder` to control the minimum lenght of masked regions on `mask=True`.

3.0.1

Fixed
- `Genes.write_scores` and `Genes.write_gff` crashing on empty `Genes` ([44](https://github.com/althonos/pyrodigal/issues/44)).

3.0.0

Added
- `MetagenomicBins` collection to store a dense array of `MetagenomicBin` objects.
- `metagenomic_bins` keyword argument to `GeneFinder` allowing to control which models are used when running gene finding in *meta* mode ([24](https://github.com/althonos/pyrodigal/issues/24)).
- `metagenomic_bin` attribute to `Genes` referencing the metagenomic model with which the genes were predicted, if in *meta* mode.
- Additional `TrainingInfo` properties (`missing_motif_weight`, `coding_statistics`).
- Setters for all remaining `TrainingInfo` properties.
- Proper `TrainingInfo` constructor with configuration option for all attributes.
- `TrainingInfo.to_dict` method to extract all parameters from a `TrainingInfo`.
- `Genes.write_genbank` method to write a GenBank record with all predicted genes from a sequence.
- `include_stop` flag to `Gene.translate` and `Genes.write_translations` to allow excluding the stop codon from the translated sequence.
- `include_translation_table` flag to `Genes.write_gff` to include the translation table to the GFF attributes of each gene.
- `gbk` output format to the Pyrodigal CLI.
- `Sequence.unknown` property exposing the number of unknown nucleotides in the sequence.
- `Sequence.start_probability` and `Sequence.stop_probability` to estimate the probability of encountering a start and a stop codon based on the GC%.

Fixed
- `Genes.write_gff` not properly reporting the number of bytes written.
- Merge several `nogil` sections in `Sequence` constructor.
- Several Cython functions missing a `noexcept` qualifier.

Changed
- **BREAKING**: Rename `OrfFinder` to `GeneFinder` for consistency.
- **BREAKING**: Use `memoryview` to expose all `TrainingInfo` attributes instead manually building lists or tuples.
- Reorganize memory management of the built-in metagenomic models.
- Make the internal Cython model public (`pyrodigal.lib`) to allow importing the underlying classes in other Cython projects.
- Use `typing.Literal` for allowed translation table values in `pyrodigal.lib` annotations
- Cache intermediate log-odds in `Nodes._raw_coding_score` to reduce calls to `pow` and `log` functions.
- Inline connection scoring functions to reduce function call overhead.
- Reorganize `struct _node` fields to reduce size in memory.
- Make `GeneFinder.find_genes` and `GeneFinder.train` reserve memory for the `Nodes` based on the GC% of the input sequence.
- Avoid storing temporary results in the generic implementation of `ConnectionScorer.compute_skippable`.
- Use Cython `freelist` for allocating `Node`, `Gene`, `MetagenomicBin` and `Mask`.
- Increase minimum allocation for `Genes` and `Nodes` to reduce early reallocations.

Removed
- **BREAKING**: `metagenomic_bin` attribute of `TrainingInfo`.

2.3.0

Changed
- Bump Cython to `v3.0.0`.

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