The 4.6.1 hotfix release contains a small configuration change to fix an issue with installing the `opentrons` PyPI package on computers running Python 3.8 and later. It does not affect the software running on your OT-2.
Known Issues
In 4.6.2 and previous releases, the OT-2 will only use TLS 1.0 for WPA2 Enterprise association. Some RADIUS servers have disabled this version of TLS; it must be enabled to connect the OT-2 to a RADIUS-secured network.
Since version 4.5.0, if a thermocycler encounters an error, the robot will be unable to recognize the error state. If your thermocycler starts blinking its yellow LED, you should cancel your protocol. See issue [8393][] for more details.
[8393]: https://github.com/Opentrons/opentrons/issues/8393